MINDRAMP PODCAST - LIVE LONG, LIVE WELL

What Causes Alzheimer's and What Can We Do To Prevent It? Interview #2 with Jesse Wiley

August 12, 2021 Michael C Patterson, Jesse Wiley Season 2 Episode 7
MINDRAMP PODCAST - LIVE LONG, LIVE WELL
What Causes Alzheimer's and What Can We Do To Prevent It? Interview #2 with Jesse Wiley
Show Notes Chapter Markers

Jesse Wiley discusses his work on the TREAT-AD project and their attempt to identify new candidates for drug development to protect against Alzheimer's. Jesse explains that he and his team have identified 15 biological domains that are associated with the development of Alzheimer's (not 18 as I say in the podcast).  

Intriguingly, Mitochondrial malfunction and chronic immune response rose to the top of the list of domains. 

Jesse also explains "pseudotime" which is a new tool for tracking the trajectory of disease development. 

Our discussion of mitochondrial malfunction led us to discussions  of epigenetic factors,  and the role of behavior and lifestyle interventions. 

Teasers
Introduction
Biological Domains That Contribute to Alzheimer's Disease
What Are the Domains?
Mitochondrial Malfunction
Pseudotime - The Trajectory of the Disease
Can We Prevent Mitochonrdrial Malfunction?
Why do Mitochondria Malfunction? - Epigenetics
Does Behavior and Lifestyle Play a Role?
What is The Desired End Result?
The Power of Healthy Living
Conclusion