Jesse Wiley discusses his work on the TREAT-AD project and their attempt to identify new candidates for drug development to protect against Alzheimer's. Jesse explains that he and his team have identified 15 biological domains that are associated with the development of Alzheimer's (not 18 as I say in the podcast).
Intriguingly, Mitochondrial malfunction and chronic immune response rose to the top of the list of domains.
Jesse also explains "pseudotime" which is a new tool for tracking the trajectory of disease development.
Our discussion of mitochondrial malfunction led us to discussions of epigenetic factors, and the role of behavior and lifestyle interventions.