Flourish As You Age
BRAIN HEALTH
MENTAL MANAGEMENT
A GOOD DEATH
Let's not just fade away; let's FLOURISH as we age!
The MINDRAMP Podcasts focus on three key components that have been shown to contribute to flourishing in the later years of your life. You will find mini-series of episodes that explore each component.
1) Keeping your brain and body healthy - see The Roots of Brain Health
2) Managing your mental states - see Flourishing
3) Planning the kind of death you want to have - (coming 10/1/24))
You will also find the occasional episodes that focus social concerns that I feel have an impact on our well-being, for example "Elections."
Flourish As You Age
BRAIN - Jesse Wiley, Part 2, What Causes Alzheimer's and What Can We Do To Prevent It?
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Jesse Wiley discusses his work on the TREAT-AD project and their attempt to identify new candidates for drug development to protect against Alzheimer's. Jesse explains that he and his team have identified 15 biological domains that are associated with the development of Alzheimer's (not 18 as I say in the podcast).
Intriguingly, Mitochondrial malfunction and chronic immune response rose to the top of the list of domains.
Jesse also explains "pseudotime" which is a new tool for tracking the trajectory of disease development.
Our discussion of mitochondrial malfunction led us to discussions of epigenetic factors, and the role of behavior and lifestyle interventions.
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